The 8 Best Luxury Resorts in Key West | Hand-Picked for 2025
We analyzed all the options and found the best luxury resorts in Key West for a stay that’s indulgent and relaxing so that you can unwind in Florida’s version of paradise.
Whether you’re after something a little sleek and modern or you’re more into that relaxed, island-style vibe with a splash of high-end comfort, these places bring it all — and then some.
Table of Contents
Methodology
For this ranking, we sifted through hundreds of reviews across multiple platforms — specifically Google Reviews, TripAdvisor, and Expedia — to figure out which luxury resorts in Key West were actually living up to the hype.
We also compared amenities, beach access, on-site dining, room types, pool setups, and what’s nearby to make sure each resort checked more than a few boxes.
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The 8 Best Key West Luxury Resorts for 2025
8. Hyatt Centric Key West Resort and Spa
Key Highlights:
- Steps from the Gulf of Mexico with private waterfront access
- 120 guest rooms, each with a private balcony
- On-site Jala Spa and SHOR American Seafood Grill
Hyatt Centric offers a kind of laid-back polish that’s very, very typical of waterfront luxury resorts in Key West. It’s right on the water, literally at the edge of Old Town, so you’re only a few steps from the action while still feeling kind of tucked away in your own mini hideaway.
The property includes just over 100 rooms, but each one is generously sized, with balconies that almost all stare straight out at the Gulf.
The spa here—Jala—is pretty complete, with treatments focused on natural ingredients and a bit of a tropical twist. Meanwhile, SHOR restaurant leans into the seafood thing hard, but in a really elevated way with seasonal dishes and an open-air dining setup that practically demands sunset photos.
Compared to some other luxury resorts Key West offers, Hyatt Centric is a bit more low-key, but honestly, that’s kind of what makes it special.
Reviews & Latest Price on TripAdvisor
7. Southernmost Beach Resort – Most Affordable
Key Highlights:
- 3 oceanfront pools and 3 beach areas
- Spacious guest rooms, many with ocean views
- Located at the quieter end of Duval Street
Southernmost Beach Resort comes in as the most budget-conscious pick on this list, but don’t let that throw you—it still punches way above its price tag.
The resort is made up of several buildings spread out across a chunk of shoreline, with a trio of pools and a surprisingly large beachfront area for something this central.
Rooms here have a mix of vibes—some are more modern while others keep that light, breezy Florida Keys energy—but all of them are super clean, well-maintained, and loaded with essentials you’d expect from Key West luxury resorts.
There’s an in-house spa, a fitness center, and multiple ocean-facing lounge spots where you can just completely switch off.
The Southernmost Beach Café serves all-day eats with ocean views, and honestly, it’s hard to beat their lobster benedict with a mimosa while your toes are basically in the sand.
Even though this one is technically the most affordable, it still offers many of the amenities you’d find at the best luxury resorts in Key West.
Reviews & Latest Price on TripAdvisor
6. Pier House Resort & Spa
Key Highlights:
- Private beach and full-service spa
- Located right next to Mallory Square
- Two restaurants and a popular beach bar
Right in the middle of everything but with a vibe that feels sort of tucked away, Pier House Resort & Spa is probably the most conveniently located option of the luxury resorts in Key West.
It’s practically next door to Mallory Square, so you’re set up perfectly for catching the sunset and wandering Duval without needing a ride.
What makes this place stand out, though, is its private beach—yes, real sand, actual privacy, and that kind of chill where you could stay horizontal all day. There’s also a spa on-site that’s both classic and relaxing, plus a massive outdoor pool that never feels overly packed thanks to the resort’s spread-out layout.
The food situation here is excellent too, especially One Duval, their oceanfront spot known for grilled snapper and thoughtfully sourced seafood.
The rooms are modern, and some suites come with views that stretch all the way to the Gulf, which is, frankly, kind of incredible at this location.
Reviews & Latest Price on TripAdvisor
5. The Gardens Hotel – Best-Seller
Key Highlights:
- Privately owned estate with just 17 rooms
- Adult-only resort and extremely quiet
- Gorgeous tropical gardens and wine gallery
The Gardens Hotel has this almost secret-garden charm going on, but with the comfort and detail you’d expect from typical Key West luxury resorts.
The whole vibe here is intimate, lush, and completely grown-up, which is probably why it’s consistently one of the best-selling luxury resorts Key West has to offer. The property itself is stunning, with paths winding through thick tropical landscaping, and a cozy pool area that feels more like a private villa than a hotel.
It’s also adults-only, and there are fewer than 20 rooms total, so privacy and peace tend to be part of the package. Rooms are designed with a more traditional flair, featuring hardwoods and soft linens, though each one includes high-end touches like pillowtop beds and private balconies or patios.
For a boutique-style stay, this might be the best luxury resort in Key West for those who love the intimate type of properties instead of big chains.
Reviews & Latest Price on TripAdvisor
4. H2o Suites Hotel
Key Highlights:
- 22 adults-only suites with plunge pools
- Rooftop pool and cabana bar
- Luxury linens, rainfall showers, and in-room wine service
H2o Suites feels like the kind of place where every single corner was designed with a little more intention than usual, especially for travelers looking for a luxury stay that’s also pretty chill.
The suites are the highlight, clearly—most come with private plunge pools, and every room is filled with things like marble touches, rainfall showers, and tech that actually works.
The rooftop pool area has major wow-factor with shaded cabanas, a sleek bar, and a setting that makes it feel much larger than it actually is.
And yet, despite the upscale finishings, it’s still quiet—no screaming kids, no loud groups, just a slow, steady rhythm that suits the Key West pace. Room service, nightly turndown, high-end bath amenities—everything’s polished but not fussy.
For those who want a boutique version of the best luxury resorts in Key West, H2o might be the exact right balance between private and posh.
Reviews & Latest Price on TripAdvisor
3. Ocean Key Resort & Spa
Key Highlights:
- Central location on Duval Street and the oceanfront
- 135 rooms with balconies overlooking the water
- Top-rated spa and on-site fine dining
Ocean Key is about as close as you can get to the action without sacrificing peace, making it one of the most convenient luxury resorts Key West has to offer.
The location is extremely central—right at Zero Duval Street—and the views from the oceanfront balconies are just ridiculously good.
The rooms come with colorful accents and oversized soaking tubs, and the suites push the whole experience further with private balconies, hardwood floors, and large living spaces that are more like high-end condos.
Their spa, SpaTerre, includes tropical-inspired treatments and deep-tissue work that’s actually worth booking ahead of time.
Then there’s Hot Tin Roof, their restaurant, which is known for Latin-Caribbean fusion plates, creative cocktails, and the kind of ambiance that makes you want to stay long after dessert.
Ocean Key stands out as one of the best luxury resorts in Key West because it manages to feel both elegant and electric at the same time.
Reviews & Latest Price on TripAdvisor
2. Oceans Edge Resort & Marina Key West – Top Value Pick
Key Highlights:
- Six pools and a full-service marina
- 175 suites with waterfront balconies
- Located on Stock Island, about 15 minutes from downtown
Oceans Edge is one of the largest properties of all the luxury resorts in Key West, and it shows—from the sheer number of pools to the extra space in each suite.
Each room has a waterfront view, and the suites are pretty massive, especially compared to what you’ll find in the Old Town area.
Even though it’s not downtown, the marina and peaceful waterfront vibe make up for it, and they offer free shuttle service to Duval Street anyway. For those who want top-tier luxury without paying that downtown premium, this is a top pick.
There’s kayaking, paddleboarding, and boat tours straight from the marina, plus Yellowfin Bar & Kitchen delivers seriously good seafood with dockside views.
If value matters to you but you’re not trying to sacrifice the resort feel, Oceans Edge is the top value pick among all Key West luxury resorts.
Reviews & Latest Price on TripAdvisor
1. Santa Maria Suites Hotel – Top Overall
Key Highlights:
- 35 luxury suites with full kitchens
- Two heated pools and poolside bar service
- Steps from South Beach and Duval Street
Santa Maria Suites lands at the top for one main reason—it consistently balances high-end service, apartment-style luxury, and pure relaxation better than anywhere else, making it the best luxury resort in Key West.
Every suite comes with two bedrooms, a gourmet kitchen, and spa-level bathrooms, which makes it ideal for longer stays or anyone who just likes having extra space.
The grounds are tropical but polished, with two heated pools surrounded by shady palms and staff who are, frankly, borderline psychic when it comes to refills and fresh towels. You’re also super close to South Beach, which makes sneaking in a sunrise walk or a salty afternoon swim totally effortless.
Meanwhile, their on-site Ambrosia restaurant brings upscale Japanese dining right to the property, and the wine list is better than most places in town.
In short, if you’re picking just one of the best luxury resorts in Key West to splurge on, Santa Maria Suites is the one you remember long after checkout.
Reviews & Latest Price on TripAdvisor
